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Tertiapin-Q

简要描述:Smartox Biotechnology是*一家专门生产动物毒液多肽毒素,用于细胞离子通道功能研究的生物医药公司。多肽毒素在生物制药领域具有重要的使用价值。

  • 产品型号:08TER001
  • 厂商性质:代理商
  • 更新时间:2024-03-26
  • 访  问  量:1279

产品介绍

 Tertiapin-Q 

 

Blocker of Kir Channels(钾通道Kir阻断剂)

 

Tertiapin has been isolated from the venom of the Honeybee  Apis melliferaTertiapin-Q is an oxidation-resistant mutant of the wild-type tertiapin where Methionine 13 has been replaced by a Glutamine.  blocks the inwardly rectifying Kir1.1 (ROMK1) and Kir3.1/3.4 (GIRK1/GIRK4 also known as IKACh) potassium channels with Kd values of around 2 nM and 8 nM respectively. also inhibits calcium-activated large conductance BK potassium channels (KCa1.1) in a concentration and voltage-dependent manner (IC50 ~ 5 nM), in addition to inhibiting Kir3.1/3.2 (GIRK1/GIRK2) heteromultimer potassium channels with a Kd close to 270 nM.  can prevent dose-dependent acetylcholine(ACh)-induced atrioventricular blocks in mammalian hearts, as KCNJ3/KCNJ5 channels (also named I(KACh)), are activated by ACh found in mammalian myocytes. 

 

技术资料

氨基酸序列:

Ala-Leu-Cys3-Asn-Cys5-Asn-Arg-Ile-Ile-Ile-Pro-His-Gln-Cys14-Trp-Lys-Lys-Cys18-Gly-Lys-Lys-NH2 

二硫键: Cys3-Cys14 and Cys5-Cys18 

长度 (aa)21 

分子式: C106H175N35O24S4 

分子量: 2452 Da 

外观:White lyophilized solid 

可溶性: water and saline buffer 

CAS 号: [252198-49-5] 

来源: Synthetic  

纯度: > 97 %

 

产品信息

08TER001-00100

Tertiapin Q

0.1mg

08TER001-00500

Tertiapin Q

0.5mg

08TER001-01000

Tertiapin Q

1mg 

 

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