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ω-agatoxin IVA(ω-漏斗网蛛毒素 IVA)

简要描述:Smartox Biotechnology是*一家专门生产动物毒液多肽毒素,用于细胞离子通道功能研究的生物医药公司。多肽毒素在生物制药领域具有重要的使用价值。

  • 产品型号:11AGA001
  • 厂商性质:代理商
  • 更新时间:2024-03-26
  • 访  问  量:2156

产品介绍

ω-agatoxin IVA / Omega agatoxin IVA(ω-漏斗网蛛毒素 IVA)

 

Blocker of P/Q-type calcium channel (Cav2.1)

P/Q型钙离子通道(Cav2.1)阻断剂

 

ω-agatoxin IVA (ω-AGA IVA) is a peptide originally isolated from funnel web-spider venom Agelenopsis aperta. This peptide is a specific blocker of P/Q-type calcium channel (Cav2.1). It has been reported that ω-agatoxin IVA is a potent blocker of voltage-gated calcium channels in insect and vertebrate central neurons. The binding site for ω-agatoxin IVA has been localized in part to the extracellular S3–S4 loop in repeat IV of the α-1A Ca2+ channels, which is proximal to the S4 sensor domain. This is coherent with its functional effect (no pore-blocking activity, but gating modifier by a shift of channel activation towards more depolarized potentials). This makes this toxin a voltage-dependent blocker of P/Q calcium channels.

 

ω-agatoxin IVA(ω-漏斗网蛛毒素 IVA)技术资料

 

氨基酸序列: 

Lys-Lys-Lys-Cys4-Ile-Ala-Lys-Asp-Tyr-Gly-Arg-Cys12-Lys-Trp-Gly-Gly-Thr-Pro-Cys19-Cys20-Arg-Gly-Arg-Gly-Cys25-Ile-Cys27-Ser-Ile-Met-Gly-Thr-Asn-Cys34-Glu-Cys36-Lys-Pro-Arg-Leu-Ile-Met-Glu-Gly-Leu-Gly-Leu-Ala-OH

二硫键:Cys4-Cys20, Cys12-Cys25, Cys19-Cys36 and Cys27-Cys34 

长度 (aa) 48

分子式: C217H360N68O60S10 

分子量: 5202.48 Da

外观:White lyophilized solid

可溶性:water and saline buffer

CAS 号: 145017-83-0 

来源:Synthetic 

纯度:> 97 %

 

产品信息

11AGA001-00100

ω-agatoxin IVA(ω-漏斗网蛛毒素 IVA)

0.1mg

11AGA001-00500

ω-agatoxin IVA(ω-漏斗网蛛毒素 IVA)

0.5mg

11AGA001-01000

ω-agatoxin IVA(ω-漏斗网蛛毒素 IVA)

1mg

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