产品介绍

Crotamine响尾蛇胺

Cell-penetrating peptide and ion channels blocker

细胞穿透肽和离子通道阻断剂

Crotamine is a basic peptide present in the venom of the South American rattlesnake Crotalus durissus terrificus. Multiple biological functions have been attributed to Crotamine. It is a natural cell-penetrating peptide with selective biological action towards actively proliferating cell types. Moreover, it has been reported that crotamine is a blocker of Kv1.3 (IC50 around 300 nM) as well as Kv1.1 and Kv1.2. It has analgesic properties and myonecrotic effects. In addition, crotamine belongs to the beta-defensin peptides and as such demonstrates antibacterial properties by interacting with lipid membranes.

Crotamine响尾蛇胺技术资料

氨基酸序列：

YKQCHKKGGHCFPKEKICLPPSSDFGKMDCRWRWKCCKKGSG-OH

二硫键：Cys⁴-Cys³⁶; Cys¹¹-Cys³⁰; Cys¹⁸-Cys³⁷

长度 (aa)： 41

分子式： C₂₁₄H₃₂₆N₆₄O₅₄S₇

分子量：4883.82 Da

外观：White lyophilized solid

可溶性： water or saline buffer

CAS 号：

来源：Synthetic

纯度：> 95%

产品信息

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