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µ-conotoxin GIIIB (u-芋螺毒素 GIIIB)

简要描述:Smartox Biotechnology是*一家专门生产动物毒液多肽毒素,用于细胞离子通道功能研究的生物医药公司。多肽毒素在生物制药领域具有重要的使用价值。

  • 产品型号:CON020
  • 厂商性质:代理商
  • 更新时间:2017-10-24
  • 访  问  量:712

产品介绍

µ-conotoxin GIIIB(µ-芋螺毒素 GIIIB)

 

Selective blocker of Nav1.4 channels(钠离子通道Nav1.4选择性阻断剂)

 

µ-conotoxin GIIIB is a 22-mer peptide originally isolated from the venom of the piscivorous marine snail Conus geographus. µ-conotoxin GIIIB adopts a compact structure consisting of a distorted 310-helix and a small ß-hairpin. µ-conotoxin GIIIB is stabilized by three disulphide bridges and is highly enriched in lysine and arginine residues, forming potential sites of interaction with Na channels. An unusual feature is the presence of three hydroxyproline residues. µ-conotoxin GIIIB is a useful probe to discriminate between neuronal and muscle sodium channels as it exhibits at least a 1000-fold specificity for muscle versus nerve sodium channels. µ-Conotoxin GIIIB selectively blocks Nav1.4(µ1) voltage-dependent sodium channels, which are predominantly expressed in muscle, with an affinity close to 20 nM.µ-Conotoxin GIIIB appears to physically occlude the channel pore by binding on site I of the Na+ channel. 

 

µ-conotoxin GIIIB 技术资料

氨基酸序列:

Arg-Asp-Cys3-Cys4-Thr-Hyp-Hyp-Arg-Lys-Cys10-Lys-Asp-Arg-Arg-Cys15-Lys-Hyp-Met-Lys-Cys20-Cys21-Ala-NH2 

二硫键: Cys3-Cys15, Cys4-Cys20 and Cys10-Cys21 

长度 (aa) 22 

分子式: C101H175N39O30S7 

分子量:2640.26 Da 

外观:White lyophilized solid 

可溶性:water and saline buffer 

CAS 号:not available 

来源: Synthetic  

纯度:> 97 %

 

产品信息

CON020-50100

µ-conotoxin GIIIB

        5x 0.01mg

CON020-00100

µ-conotoxin GIIIB

0.1mg

CON020-00500

µ-conotoxin GIIIB

0.5mg

CON020-01000

µ-conotoxin GIIIB

1mg

 

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