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Apamin(蜜蜂神经毒素)

简要描述:Smartox Biotechnology是*一家专门生产动物毒液多肽毒素,用于细胞离子通道功能研究的生物医药公司。多肽毒素在生物制药领域具有重要的使用价值。

  • 产品型号:08APA001
  • 厂商性质:代理商
  • 更新时间:2024-03-25
  • 访  问  量:1348

产品介绍

Apamin 

 

Inhibitor of small conductance Ca2+-activated K+ channels

小电导钙激活钾离子通道抑制剂

 

Apamin is a neurotoxin that was originally isolated from Apis mellifera. Apamin binds to and inhibits the  SK channels(small conductance Ca2+-activated K+ channels) in the brain and spinal cord. Apamin inhibits three subtypes of SK channels (KCa2.1, KCa2.2, and KCa2.3) with different affinity. Apamin does not affect KCa3.1 channel activity. Apaminmost likely acts as a pore blocker such as Scyllatoxin or Tamapin, although residues both inside and outside of the pore region of the SK channels participate in apamin binding. The SK channels are present in a wide range of excitable and non-excitable cells, including cells in the central nervous system, intestinal myocytes, endothelial cells, and hepatocytes.

 

Apamin 技术资料

氨基酸序列:

 H-Cys1-Asn-Cys3-Lys-Ala-Pro-Glu-Thr-Ala-Leu-Cys11-Ala-Arg-Arg-Cys15-Gln-Gln-His-NH2 

二硫键:Cys1-Cys11 and Cys3-Cys15 

长度 (aa) 18

分子式: C79H131N31O24S4 

分子量:2027.34 Da

外观: White lyophilized solid

可溶性:water and saline buffer

CAS 号: [24345-16-2]

来源: Synthetic 

纯度: > 98 %

 

产品信息

08APA001-00500

Apamin

0.5mg

08APA001-01000

Apamin

1mg

 

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