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AmmTx3

简要描述:Smartox Biotechnology是*一家专门生产动物毒液多肽毒素,用于细胞离子通道功能研究的生物医药公司。多肽毒素在生物制药领域具有重要的使用价值。

  • 产品型号:AMX001
  • 厂商性质:代理商
  • 更新时间:2024-03-25
  • 访  问  量:1027

产品介绍

AmmTx3 

 

Blocker of A-type potassium channels(A型钾离子通道阻断剂)

 

AmmTx3 has been originally isolated from the venom of the scorpion Androctonus mauretanicus and is now offered bySmartox in its synthetic version.  binds on its target A-type potassium channel with an affinity of 66 pM in rat brain synaptosomes (Kv4 channels). As such,  should represent an excellent tool to study action potential firing frequency, spike initiation and waveform in excitable cells.  was indeed found to block A-type potassium currents from cerebellum granular cells and from striatum neurons but with IC50 values of 130 nM.  appears to be a pore blocker of Kv4.2 and Kv4.3 and seems to require the expression of the Kv4 associated protein DPP6. It should also contribute to our understanding of learning, memory and behavior.  shares very high sequence homology with two other A-type potassium channel blockers, Aa1 from Androctonus australis (94%) and BmTx3 from Buthus martensi (91%), and according to binding experiments the same channel target as well.  is a member of the a-KTX 15 family of toxins and consist of a single chain of 37 amino acid residues, with an N-terminal pyroglutamate, cross-linked by three disulfide bridges.

 

技术资料

氨基酸序列:

Pyr-Ile-Glu-Thr-Asn-Lys-Lys-Cys8-Gln-Gly-Gly-Ser-Cys13-Ala-Ser-Val-Cys17-Arg-Lys-Val-Ile-Gly-Val-Ala-Ala-Gly-Lys-Cys28-Ile-Asn-Gly-Arg-Cys33-Val-Cys35-Tyr-Pro-OH 

二硫键:Cys8-Cys28, Cys13-Cys33 and Cys17-Cys35 

长度 (aa) 37

分子式: C158H263N51O47S6  

分子量:3821.52  Da

外观:white lyophilized solid

可溶性:water or saline buffer

CAS 号:not available 

来源:Synthetic

纯度:> 98%

 

产品信息

AMX001-50010

       5 x 0.01mg

AMX001-00100

0.1mg

AMX001-00500

0.5mg

AMX001-01000

1mg

 

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