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Biotinyl-ProTx-II(生物素-原毒素-II)

简要描述:Smartox Biotechnology是*一家专门生产动物毒液多肽毒素,用于细胞离子通道功能研究的生物医药公司。多肽毒素在生物制药领域具有重要的使用价值。

  • 产品型号:12PTB002
  • 厂商性质:代理商
  • 更新时间:2024-03-25
  • 访  问  量:1208

产品介绍

Biotinyl-ProTx-II(生物素-原毒素 II)

 

ProTx-II (Protoxin-II) is a toxin that was originally isolated from Thrixopelma pruriens (Peruvian green velvet tarantula).ProTx-II inhibits both tetrodotoxin-sensitive and tetrodotoxin-resistant channels. ProTx-II inhibits activation by shifting the voltage-dependence of c hannel activation to more positive potentials. ProTx-II potently inhibits all sodium channel subtypes tested (Nav1.2/SCN2A, Nav1.5/SCN5A, Nav1.7/SCN9A, and Nav1.8/SCN10A). It is approximay 15-fold more potent on Nav1.7/SCN9A than on Nav1.5/SCN5A channels and acts on Cav3.1/CACNA1G and interacts more weakly with the related T-Type channel Cav3.2/CACNA1H but potently inhibits the L-type calcium channel Cav1.2/CACNA1C. ProTx-II also binds to phospholipids. ProTx-II, a selective inhibitor of Nav1.7 sodium channels, blocks action potential propagation in nociceptors. 

Biotinyl-ProTx-II is a N-ter biotin labeled version of the wild-type  ProTx-II useful for a wide range of experimentations.

 

Biotinyl-ProTx-II技术资料

氨基酸序列:

Biotin-Tyr-Cys2-Gln-Lys-Trp-Met-Trp-Thr-Cys9-Asp-Ser-Glu-Arg-Lys-Cys15-Cys16-Glu-Gly-Met-Val-Cys21-Arg-Leu-Trp-Cys25-Lys-Lys-Lys-Leu-Trp-OH 

二硫键:Cys2-Cys16, Cys9-Cys21 and Cys15-Cys25 

长度 (aa) 30 

分子式: C178H254N48O43S9 

分子量:4052.74 Da 

外观: White lyophilized solid 

可溶性: water and saline buffer 

CAS 号:not available 

来源:Synthetic  

纯度:> 88 %

 

产品信息

12PTB002-00100

Biotinyl-ProTx II

0.1mg

12PTB002-00500

Biotinyl-ProTx II

0.5mg

 

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