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Huwentoxin-IV(虎纹捕鸟蛛神经毒素-IV)
TTX-S selective blocker(电压门控钠离子通道TTX-S选择性阻断剂)
Huwentoxin IV (HwTx-IV) is a neurotoxin that was originally isolated from Haplopelma schmidti (Chinese bird spider). This lethal neurotoxin acts selectively on tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channels, with an IC50 of 30 nM in rat DRG neurons. It preferentially inhibits neuronal voltage-gated sodium channel subtype hNav1.7 (SCN9A, IC50 is 26 nM), rNav1.2 (SCN2A, IC50 is 150 nM), and rNav1.3 (SCN3A, IC50 is 338 nM), compared with muscle subtypes rNav1.4 (SCN4A) and hNav1.5 (SCN5A) (IC50 is > 10 µM).Huwentoxin IV inhibits the activation of sodium channels by trapping the voltage sensor of domain II of the site 4 in the inward, closed configuration.
Huwentoxin-IV(虎纹捕鸟蛛神经毒素-IV)技术资料
氨基酸序列:
Glu-Cys2-Leu-Glu-Ile-Phe-Lys-Ala-Cys9-Asn-Pro-Ser-Asn-Asp-Gln-Cys16-Cys17-Lys-Ser-Ser-Lys-Leu-Val-Cys24-Ser-Arg-Lys-Thr-Arg-Trp-Cys31-Lys-Tyr-Gln-Ile-NH2
二硫键:Cys2-Cys17, Cys9-Cys24 and Cys16-Cys31
长度 (aa):35
分子式:C174H277N51O52S6
分子量:4109.18 Da
外观:White lyophilized solid
可溶性: water and saline buffer
CAS 号:not available
来源:Synthetic
纯度:> 97 %
产品信息
08HWT002-00100 | Huwentoxin IV | 0.1mg |
08HWT002-00500 | Huwentoxin IV | 0.5mg |
08HWT002-01000 | Huwentoxin IV | 1mg |