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Huwentoxin-I(虎纹捕鸟蛛神经毒素-I)

简要描述:Smartox Biotechnology是*一家专门生产动物毒液多肽毒素,用于细胞离子通道功能研究的生物医药公司。多肽毒素在生物制药领域具有重要的使用价值。

  • 产品型号:07HWT001
  • 厂商性质:代理商
  • 更新时间:2024-03-26
  • 访  问  量:1320

产品介绍

Huwentoxin-I(虎纹捕鸟蛛神经毒素-I) 

 

Blocker of N-type Ca2+ channel and TTX-S channels

N型钙通道和TTX敏感型(TTX-S)通道阻断剂

                    TTX- S: 细胞河豚毒素敏感型钠电流

 

Huwentoxin-I (HwTx-I) is a neurotoxin that was originally isolated from the venom of the Chinese bird spider Ornithoctonus huwena. Huwentoxin-I is known to be an inhibitor of tetrodotoxin-sensitive voltage-gated sodium channels (TTX-S) (IC50 ~ 50 nM) and N-type voltage-sensitive calcium channels (IC50 ~ 100 nM) in mammalian DRG, hippocampus and insect's DUM neurons. It has only a very weak effect on L-type calcium channels, no effect on TTX-R channels and has virtually no effect on muscle sodium channels.  The selectivity  of Huwentoxin-I  for calcium channels appears to be higher than  ω-conotoxin MVIIA and equivalent to  ω-conotoxin GVIAHuwentoxin-I demonstrated an antinociceptive effect in the rat model of the formalin test when administrated intrathecally (ED50 ~ 0.28 µg/kg), without side effects of the ones led by  ω-conotoxin MVIIA.

 

Huwentoxin-I 技术资料

氨基酸序列:

 Ala-Cys2-Lys-Gly-Val-Phe-Asp-Ala-Cys9-Thr-Pro-Gly-Lys-Asn-Glu-Cys16-Cys17-Pro-Asn-Arg-Val-Cys22-Ser-Asp-Lys-His-Lys-Trp-Cys26-Lys-Trp-Lys-Leu-OH 

二硫键: Cys2-Cys17, Cys9-Cys22 and Cys16-Cys29  

长度 (aa)33 

分子式:C168H250N46O41S6 

分子量: 3751.77 Da 

外观:White lyophilized solid 

可溶性:water and saline buffer 

CAS 号:not available 

来源: Synthetic  

纯度: > 97 %

 

产品信息

07HWT001-00100

Huwentoxin-I

0.1mg

07HWT001-00500

Huwentoxin-I

0.5mg

07HWT001-01000

Huwentoxin-I

1mg

 

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