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Jingzhaotoxin III(JZTx-III,敬钊缨毛蛛毒素-III)

简要描述:Smartox Biotechnology是*一家专门生产动物毒液多肽毒素,用于细胞离子通道功能研究的生物医药公司。多肽毒素在生物制药领域具有重要的使用价值。

  • 产品型号:12JZH003
  • 厂商性质:代理商
  • 更新时间:2024-03-26
  • 访  问  量:1877

产品介绍

 Jingzhaotoxin IIIJZTx-III,敬钊缨毛蛛毒素-III

 

Selective blocker of Nav1.5 channel(钠离子通道Nav1.5选择性阻断剂)

 

Jingzhaotoxin-III (ß-TRTX-Cj1α) has been isolated initially from the Chinese Tarantula spider Chilobrachys Jingzhaovenom. Jingzhaotoxin-III selectively inhibits the activation of the voltage-dependent sodium channel Nav1.5 with an IC50value close to 350 nM. It is inactive on Nav1.2, Nav1.4, Nav1.6 and Nav1.7 and should therefore be considered as an interesting research tool to discriminate between sodium channel subtypes. Jingzhaotoxin-III binds onto receptor site 4 presumably located on DIIS3-S4 linker of Nav1.5 and supposedly blocks Nav1.5 through a different mechanism than ProTx-II and  Huwentoxin IV. ß-TRTX-Cj1α is composed of 36 amino acid residues including 6 cysteines cross-linked according to a C1-C4, C2-C5 and C3-C6 pattern. Jingzhaotoxin-III also inhibits Kv2.1 channel with an IC50 of around 700 nM. 

 

Jingzhaotoxin-III(敬钊缨毛蛛毒素-III)技术资料

氨基酸序列:Asp-Gly-Glu-Cys4-Gly-Gly-Phe-Trp-Trp-Lys-Cys11-Gly-Arg-Gly-Lys-Pro-Pro-Cys18-Cys19-Lys-Gly-Tyr-Ala-Cys24-Ser-Lys-Thr-Trp-Gly-Trp-Cys31-Ala-Val-Glu-Ala-Pro-OH 

二硫键: Cys4-Cys19, Cys11-Cys24, and Cys18-Cys31 

长度(aa):36 

分子式:C174H241N47O46S6 

分子量: 3919.53 Da 

外观:White lyophilized solid 

可溶性:aqueous buffer 

CAS号:not available 

来源:Synthetic 

纯度:> 98%

 

产品信息

12JZH003-00100

JZTx-III

0.1mg

12JZH003-00500

JZTx-III

0.5mg

12JZH003-01000

JZTx-III

1mg 

 

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