Rho-conotoxin TIA （Rho -芋螺毒素TIA ）

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Rho-conotoxin TIA （Rho -芋螺毒素TIA ）

Blocker of α1-adrenoreceptor（肾上腺素受体α1阻断剂）

Rho-conotoxin TIA has been isolated from the venom of the fish-hunting marine cone snail Conus tulipa. Rho-conotoxin TIA is a selective antagonist of α₁-adrenoreceptor (α_1A-, α_1B- and α_1D-AR). It acts non-competitively ontoα_1B-adrenoreceptor but competitively on α_1A-adrenoreceptor and α_1D-adrenoreceptor. The most important residue for activity is Arg⁴. Rho-conotoxin TIA is 10-fold selective for human α_1B-adrenoreceptor over 

α_1A-adrenoreceptor and α_1D-adrenoreceptor. The IC₅₀ values for Rho-conotoxin TIA for inhibition of ¹²⁵I-BE were 18 nM for human α_1A-AR, 2 nM for α_1B-AR and 25 nM for α_1D-AR.

Rho-conotoxin TIA 技术资料

氨基酸序列：Phe-Asn-Trp-Arg-Cys⁵-Cys⁶-Leu-Ile-Pro-Ala-Cys¹¹-Arg-Arg-Asn-His-Lys-Lys-Phe-Cys¹⁹-NH₂ 
二硫键： Cys⁵-Cys¹¹ and Cys⁶-Cys¹⁹ 
长度 (aa)：19 
分子式：C₁₀₅H₁₆₀N₃₆O₂₁S₄  
分子量： 2390.90 Da 
外观： White lyophilized solid 
可溶性：aqueous buffer 
CAS 号： not available 
来源： Synthetic 
纯度：> 97 %

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