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Vanillotoxin 3(VaTx3)

简要描述:Smartox Biotechnology是*一家专门生产动物毒液多肽毒素,用于细胞离子通道功能研究的生物医药公司。多肽毒素在生物制药领域具有重要的使用价值。

  • 产品型号:10VAN003
  • 厂商性质:代理商
  • 更新时间:2017-09-27
  • 访  问  量:525

产品介绍

 Vanillotoxin 3(VaTx3)

 

选择性激活哺乳动物辣椒素受体(TRPV1)

 

Vanillotoxin 3: Toxin description

Vanillotoxin-3 (VaTx3) has been isolated from the venom of Psalmopoeus cambridgei, a West Indies tarantula. It is a 34 amino acids peptide with three disulfide bridges with an ICK motif. It selectively activates mammalian TRPV1 (capsaicin receptor), a non-selective cation channel expressed by sensory neurons of the pain pathway with an EC50 value of 0.45 ± 0.04 µM. It is more potent than VaTx1 (20-fold) and VaTx2 (2-fold), two other analogues of VaTx3 with closely related sequences and isolated from the same venom. VaTx3 probably interacts with distinct regions of the channel than capsaicin. VaTx3 does not affect TRPV2, TRPV3, TRPV4, TRPA1, TRPM8, Kv1.2 (KCNA2), Kv2.1 (KCNB1) or Kv4.2 (KCND2). In mice, VaTx3 elicits pain-related behaviors, such as licking and flinching of the affected limb. Edema is evidenced in the paw of toxin-injected mice.  

 

氨基酸序列:

Glu-Cys2-Arg-Trp-Tyr-Leu-Gly-Gly-Cys9-Lys-Glu-Asp-Ser-Glu-Cys15-Cys16-Glu-His-Leu-Gln-Cys21-His-Ser-Tyr-Trp-Glu-Trp-Cys28-Leu-Trp-Asp-Gly-Ser-Phe-NH2 

二硫键:Disulfide bonds between Cys2-Cys16, Cys9-Cys21 and Cys15-Cys28 

长度 (aa)34  

分子式: C184H241N47O55S6 

分子量:4179.6 Da 

外观: White lyophilized solid 

可溶性: may be difficult to solubilize 

CAS 号: not available 

来源:Synthetic 

纯度: > 98%

 

产品信息

10VAN003-00100

VaTx3

0.1mg 

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