产品介绍

ω-Conotoxin MVIIA / Omega-conotoxin MVIIA(ω-漏斗网蛛毒素MVIIA) 

Blocker of N-type voltage-gated calcium channels

N型电压门控钙通道阻断剂

ω-Conotoxin MVIIA (omega-conotoxin MVIIA) has been isolated from the venom of the cone Conus magus. Omega-conotoxins act at presynaptic membranes, they bind and block voltage-sensitive calcium channels (VSCC).  ω-conotoxin MVIIA blocks N-type voltage-gated calcium channels (Ca_v2.2/CACNA1B). ω-conotoxin MVIIA is available as analgesic drug under the name Prialt^®. It blocks acute pain in patients who no longer obtain relief from opiate drugs. It is 100 to 1.000 times more potent than morphine. This toxin blocks calcium channels and disables nerves that transmit pain signals.

ω-Conotoxin MVIIA (ω-漏斗网蛛毒素MVIIA)技术资料

氨基酸序列：

 Cys¹-Lys-Gly-Lys-Gly-Ala-Lys-Cys⁸-Ser-Arg-Leu-Met-Tyr-Asp-Cys¹⁵-Cys¹⁶-Thr-Gly-Ser-Cys²⁰-Arg-Ser-Gly-Lys-Cys²⁵-NH₂ 

二硫键：Cys¹-Cys¹⁶, Cys⁸-Cys²⁰ and Cys¹⁵-Cys²⁵ 

长度 (aa)：25 

分子式：C₁₀₂H₁₇₂N₃₆O₃₂S₇ 

分子量： 2639.18 Da 

外观：White lyophilized solid 

可溶性： water and saline buffer 

CAS 号： [107452-89-1] 

来源：Synthetic  

纯度：> 97 %

产品信息