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ω-Conotoxin MVIIC / Omega conotoxin MVIIC (ω-漏斗网蛛毒素MVIIC)
Blocker of P/Q and N-type Ca2+ channels
P/Q型钙通道和N型钙通道阻断剂
ω-conotoxin MVIIC (omega conotoxin MVIIC) has been isolated from the venom of the cone Conus magus. ω-conotoxin MVIIC is a blocker of P/Q and N-type calcium channels. It inhibits presynaptic Ca2+ channels, including the Ca2+ channels responsible for Ca2+ uptake by rat brain synaptosomes, the P-type Ca2+ channels in cerebellar Purkinje cells, and a significant fraction of ω-conotoxin GVIA-resistant currents in hippocampal CA1 neurons. ω-conotoxin MVIIC also presents an inhibition of ω-conotoxin GVIA-resistant depolarization-induced neurotransmitter release in cerebellar neurons of rats.
ω-conotoxin MVIIC (ω-漏斗网蛛毒素MVIIC) 技术资料
氨基酸序列:
Cys1-Lys-Gly-Lys-Gly-Ala-Pro-Cys8-Arg-Lys-Thr-Met-Tyr-Asp-Cys15-Cys16-Ser-Gly-Ser-Cys20-Gly-Arg-Arg-Gly-Lys-Cys26-NH2
二硫键:Cys1-Cys16, Cys8-Cys20 and Cys15-Cys26
长度 (aa):26
分子式:C106H178N40O32S7
分子量:2750.20 Da
外观:White lyophilized solid
可溶性:water and saline buffer
CAS 号:[147794-23-8]
来源: Synthetic
纯度: > 97 %
产品信息
08CON002-00100 | ω-conotoxin MVIIC(ω-漏斗网蛛毒素MVIIC) | 0.1mg |
08CON002-00500 | ω-conotoxin MVIIC(ω-漏斗网蛛毒素MVIIC) | 0.5mg |
08CON002-01000 | ω-conotoxin MVIIC(ω-漏斗网蛛毒素MVIIC) | 1mg |