关键词搜索: 3D细胞培养相关产品,多肽毒素,原代细胞,细胞因子,抗体,试剂盒,各类细菌、病毒荧光定量PCR试剂盒,转基因检测仪器和耗材等。

你的位置:首页 > 产品展示 > > 离子通道研究用多肽毒素 >ProTx-III,新的选择性Nav1.7通道阻断剂

产品详细页

ProTx-III,新的选择性Nav1.7通道阻断剂

简要描述:Smartox Biotechnology是*一家专门生产动物毒液多肽毒素,用于细胞离子通道功能研究的生物医药公司。多肽毒素在生物制药领域具有重要的使用价值。

  • 产品型号:PTX003
  • 厂商性质:代理商
  • 更新时间:2016-05-12
  • 访  问  量:783

产品介绍

ProTx-III

ProTx-III, new selective Nav1.7 blocker

ProTx-III,新的选择性Nav1.7通道阻断剂

 

ProTx-III (µ-TRTX-Tp1a; belongs to NaSpTx family 1) has been isolated from the venom of the Peruvian green-velvet tarantula Thrixopelma pruriens at the University of Queensland (Australia). ProTx-III has been described to be a selective inhibitor of Nav1.7 with an IC50 value around 2 nM. The synthetic version of Tp1a produced by Smartox yields similar results in terms of Nav1.7 inhibition (see Figure 1). Queensland scientists have described that ProTx-III induces no significant changes in the voltage dependence of activation or steady-state inactivation of Nav1.7. ProTx-III also inhibits Nav1.1, Nav1.2 and Nav1.6 at nanomolar concentrations and does not affects Cav channels and nicotinic acetylcholine receptors. ProTx-III demonstrates analgesic propertiesin vivo when injected intraplantary in mice prior treatment with OD1, an activator of Nav1.7, which induces spontaneous pain.

Fig 1: effect of 5nM Smartox ProTx-III on hNav1.7 current studied by eliciting voltage steps from -60 to +40 mV at a holding potential of -90 mV.

 

ProTx-III技术资料

 

氨基酸序列:

Asp-Cys2-Leu-Lys-Phe-Gly-Trp-Lys-Cys9-Asn-Pro-Arg-Asn-Asp-Lys-Cys16-Cys17-Ser-Gly-Leu-Lys-Cys22-Gly-Ser-Asn-His-Asn-Trp-Cys29-Lys-Leu-His-Ile-NH2

二硫键:Cys2-Cys17, Cys9-Cys22, Cys16-Cys29

长度 (aa) 33

分子式: C162H246N52O43S6

分子量:3802.47 Da

外观:White lyophilized solid

可溶性: Water or saline buffer, 5 mg/mL maximum (recommendation)

Counterion: TFA salts

CAS 号:not available 

来源:Synthetic

 

产品信息

货号

名称

规格

PTX003

ProTx-III

100ug/500ug/1000ug/5×10ug

 

北京群晓科苑是Smartox Biotechnology授权代理商,如果您对Smartox产品感兴趣,咨询。

留言框

  • 产品:

  • 您的单位:

  • 您的姓名:

  • 联系电话:

  • 常用邮箱:

  • 省份:

  • 详细地址:

  • 补充说明:

  • 验证码:

    请输入计算结果(填写阿拉伯数字),如:三加四=7
在线咨询
电话咨询
13581534696
关注微信