产品介绍

Waglerin-1-FAM （羧基荧光素标记的Waglerin-1）

Waglerin-1 blocks muscle nAChRs

阻断肌肉乙酰胆碱受体

Waglerin-1 (Wtx-1) is a peptide originally isolated from the venom of the Wagler’s pit viper (Trimeresurus wagleri). This 22 amino-acid peptide is a competitive antagonist of adult muscle nicotinic acetylcholine receptors. Waglerin-1 binds selectively to epsilon subunit of nAChR. Some studies have demonstrated that Waglerin-1 has an effect on ionotropic GABA receptors. It may potentiate or depress I(GABA) depending on the neurons. Some derivatives of Waglerin-1 are currently used in cosmetics to reduce wrinkles. The fluorescent derivative Waglerin-1-FAM can be use to explore the expression and function of the adult nAChR subtypes.

Waglerin-1-FAM技术资料

氨基酸序列：

FAM-Gly-Gly-Lys-Pro-Asp-Leu-Arg-Pro-Cys⁹-His-Pro-Pro-Cys¹³-His-Tyr-Ile-Pro-Arg-Pro-Lys-Pro-Arg-OH

二硫键： Cys⁹-Cys¹³

长度 (aa)： 22

分子式：C₁₃₃H₁₈₅N₃₇O₃₂S₂

分子量：2878.27 Da

CAS 号：NA

来源：Synthetic

荧光染料：FAM, 5(6)-carboxyfluorescein (λex 492, λem 517)

产品信息

北京群晓科苑是Smartox Biotechnology授权代理商，如果您对Smartox产品感兴趣，咨询。