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产品介绍
GaTx2
Selective blocker of ClC2 (CLCN2) chloride channels
氯离子通道蛋白2(CLCN2、CLC2)选择性阻断剂
GaTx2 (gating modifier of anion channels 2) was isolated from the venom of Leiurus quinquestriatus hebraeus. is the most potent peptide inhibitor of ClC-2 (CLCN2) chloride channel ever described. Kd value is close to 20 pM. slows ClC-2 activation but without altering channel conductance. The effect is voltage-dependent. This inhibitory effect was highlighted on rabbit ClC-2 channels expressed in oocytes. It has no effect on ClC-0, ClC-1, ClC-3, ClC-4, CFTR, GABAC, Xenopus ClCa, Shaker B or Kv1.2 channels. Structurally, is composed of two β-strands and one α-helix. This peptide is also called Leiuropeptide II. Bears 89, 93 and 96% identity with OdK1, neurotoxin PO1 and leiuropeptide III, respectively.
技术资料
氨基酸序列:
H-Val-Ser-Cys3-Glu-Asp-Cys6-Pro-Asp-His-Cys10-Ser-Thr-Gln-Lys-Ala-Arg-Ala-Lys-Cys19-Asp-Asn-Asp-Lys-Cys24-Val-Cys26-Glu-Pro-Ile-OH
二硫键: Disulfide bonds between Cys3-Cys19, Cys6-Cys24, and Cys10-Cys26
长度 (aa):29
分子式: C125H199N39O47S6
分子量: 3191.25 Da
外观: White lyophilized solid
可溶性:water and saline buffer
CAS 号:not available
来源:Synthetic
纯度: > 98 %
产品信息
10GTX002-00100 | 0.1mg | |
10GTX002-00500 | 0.5mg | |
10GTX002-01000 | 1mg |
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