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GaTx2

简要描述:Smartox Biotechnology是*一家专门生产动物毒液多肽毒素,用于细胞离子通道功能研究的生物医药公司。多肽毒素在生物制药领域具有重要的使用价值。

  • 产品型号:10GTX002
  • 厂商性质:代理商
  • 更新时间:2017-09-30
  • 访  问  量:616

产品介绍

GaTx2 

 

Selective blocker of ClC2 (CLCN2) chloride channels

氯离子通道蛋白2CLCN2CLC2)选择性阻断剂

 

GaTx2 (gating modifier of anion channels 2) was isolated from the venom of Leiurus quinquestriatus hebraeus.  is the most potent peptide inhibitor of ClC-2 (CLCN2) chloride channel ever described. Kd value is close to 20 pM. slows ClC-2 activation but without altering channel conductance. The effect is voltage-dependent. This inhibitory effect was highlighted on rabbit ClC-2 channels expressed in oocytes. It has no effect on ClC-0, ClC-1, ClC-3, ClC-4, CFTR, GABAC, Xenopus ClCa, Shaker B or Kv1.2 channels. Structurally,  is composed of two β-strands and one α-helix. This peptide is also called Leiuropeptide II. Bears 89, 93 and 96% identity with OdK1, neurotoxin PO1 and leiuropeptide III, respectively.

 

技术资料

氨基酸序列:

H-Val-Ser-Cys3-Glu-Asp-Cys6-Pro-Asp-His-Cys10-Ser-Thr-Gln-Lys-Ala-Arg-Ala-Lys-Cys19-Asp-Asn-Asp-Lys-Cys24-Val-Cys26-Glu-Pro-Ile-OH

二硫键: Disulfide bonds between Cys3-Cys19, Cys6-Cys24, and Cys10-Cys26

长度 (aa)29

分子式: C125H199N39O47S6   

分子量: 3191.25 Da

外观: White lyophilized solid

可溶性:water and saline buffer

CAS 号:not available

来源:Synthetic 

纯度: > 98 %

 

产品信息

10GTX002-00100

0.1mg

10GTX002-00500

0.5mg

10GTX002-01000

1mg

 

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