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Hainantoxin-III(海南捕鸟蛛毒素-Ⅲ)

简要描述:Smartox Biotechnology是*一家专门生产动物毒液多肽毒素,用于细胞离子通道功能研究的生物医药公司。多肽毒素在生物制药领域具有重要的使用价值。

  • 产品型号:13HTX003
  • 厂商性质:代理商
  • 更新时间:2024-03-26
  • 访  问  量:1467

产品介绍

 Hainantoxin-III(海南捕鸟蛛毒素 III) 

 

Selective blocker of TTX-S VGSC(电压门控钠离子通道TTX-S选择性阻断剂)

 

Hainantoxin-III (HNTX-III) is a peptide that has been isolated from the venom of the Chinese bird spider Seleconosmia hainana.  Hainantoxin-III specifically blocks mammalian neuronal tetrodotoxin-sensitive voltage-gated sodium channels (VGSCs). Hainantoxin III was found inactive on tetrodotoxin-resistant VGSCs and voltage-gated Ca2+channels (both high and low voltage-activated). 

Hainantoxin-III strongly depressed the amplitude of rat DRG tetrodotoxin-sensitive Na+ currents with an IC50 value of 1.1 nM. Like  Hainantoxin-IVHainantoxin-III causes a hyperpolarizing shift of about 10 mV in the voltage midpoint of steady-state Na+ channel inactivation. Similar to  Huwentoxin-IVHainantoxin-III and  Hainantoxin-IV do not affect the activation and inactivation kinetics of Na+ currents. 

Hainantoxin-III inhibits Nav1.7 current amplitude without significantly altering the activation and inactivation kinetics.Hainantoxin-III increases the deactivation of the Nav1.7 current after extreme depolarizations. Hainantoxin-III seems to interact with site 4 and to trap the domain II voltage sensor in the closed state. The inhibition of Nav1.7 by hainantoxin-III is reversible upon washing, but no reversibility was observed for  Hainantoxin-IV and  Huwentoxin-IV

Hainantoxin-III was shown to block Nav1.1, Nav1.2, Nav1.3 and Nav1.7 expressed in HEK293 cells with IC50 values of 1.27 µM, 275 nM, 491 nM and 232 nM, respectively.

 

Hainantoxin-III 技术资料

氨基酸序列:

Gly-Cys2-Lys-Gly-Phe-Gly-Asp-Ser-Cys9-Thr-Pro-Gly-Lys-Asn-Glu-Cys16-Cys17-Pro-Asn-Tyr-Ala-Cys22-Ser-Ser-Lys-His-Lys-Trp-Cys29-Lys-Val-Tyr-Leu-NH2 

二硫键:Cys2-Cys17, Cys9-Cys22, and Cys16-Cys29 

长度 (aa) 33 

分子式: C154H228N44O45S6  

分子量:3608.20 Da  

外观: White lyophilized solid 

可溶性:water and saline buffer 

CAS 号:Not available 

来源:Synthetic  

纯度: > 97%

 

产品信息

13HTX003-00100

Hainantoxin III

0.1mg

13HTX003-00500

Hainantoxin III

0.5mg

13HTX003-01000

Hainantoxin III

1mg 

 

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