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Stromatoxin-1 / ScTx1

简要描述:Smartox Biotechnology是*一家专门生产动物毒液多肽毒素,用于细胞离子通道功能研究的生物医药公司。多肽毒素在生物制药领域具有重要的使用价值。

  • 产品型号:SCT01
  • 厂商性质:代理商
  • 更新时间:2024-03-26
  • 访  问  量:1683

产品介绍

Stromatoxin-1 / ScTx1 

 

Blocker of Kv2 channels(钾离子通道Kv2阻断剂)

 

Stromatoxin-1 (ScTx-1) has been isolated from the venom of the African tarentula Stromatopelma calceata.Stromatoxin-1 is a 34 amino-acid long peptide that belongs to the structural family of inhibitor cystine knot peptides reticulated by three disulfide bridges. It has an amidated C-terminus and bears strong homology with hanatoxin 1 (83%).Stromatoxin-1 inhibits with high affinities Kv2.1 and Kv2.2, that encode delayed K+ channels (respectively, with IC50 of 12 and 21 nM). The block is voltage-dependent and slowly reversible. Stromatoxin-1 is also a very sensitive inhibitor of Kv4.2, that encodes a transient K+ current (IC50 of 1.2 nM). Here also, the block is voltage-dependent indicating that ScTx-1 acts as a gating modifier rather than a pore blocker. Reversibility is faster on Kv4.2 channels. In contrast,Stromatoxin-1 has no effect on Kv1.1, Kv1.2, Kv1.3, Kv1.4, Kv1.5, Kv1.6 or Kv3.4 channels. The toxin has also no effect on voltage-dependent Na+ and Ca2+ channels of cerebellar granule cells. Stromatoxin-1 was found to increase the spontaneous phasic contraction amplitude, muscle force and tone in isolated rat urinary bladder smooth muscle. It also enhances myogenic constriction in pressurized arterial segments. 

 

Stromatoxin-1 技术资料

氨基酸序列:

Asp-Cys2-Thr-Arg-Met-Phe-Gly-Ala-Cys9-Arg-Arg-Asp-Ser-Asp-Cys15-Cys16-Pro-His-Leu-Gly-Cys21-Lys-Pro-Thr-Ser-Lys-Tyr-Cys28-Ala-Trp-Asp-Gly-Thr-Ile-NH2 

二硫键: Cys2-Cys16, Cys9-Cys21 and Cys15-Cys28 

长度 (aa) 34

分子式: C156H237N49O48S7 

分子量:3791,3 Da

外观: white lyophilized solid

可溶性: water or saline buffer

CAS 号:not available 

来源: Synthetic

纯度: > 98%

 

产品信息

SCT01-50010

Stromatoxin-1

          5 x 0.01mg

SCT01-00100

Stromatoxin-1

0.1mg

SCT01-00500

Stromatoxin-1

0.5mg

SCT01-01000

Stromatoxin-1

1mg

 

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