关键词搜索: 3D细胞培养相关产品,多肽毒素,原代细胞,细胞因子,抗体,试剂盒,各类细菌、病毒荧光定量PCR试剂盒,转基因检测仪器和耗材等。

你的位置:首页 > 产品展示 > > 离子通道研究用多肽毒素 >Mambalgin-1

产品详细页

Mambalgin-1

简要描述:Smartox Biotechnology是*一家专门生产动物毒液多肽毒素,用于细胞离子通道功能研究的生物医药公司。多肽毒素在生物制药领域具有重要的使用价值。

  • 产品型号:MAM001-50010
  • 厂商性质:代理商
  • 更新时间:2016-05-12
  • 访  问  量:770

产品介绍

Mambalgin-1

ASIC1a & 1b channel blocker

酸敏感离子通道ASIC1a & 1b通道阻断剂

 

Mambalgin-1 was initially isolated by Sylvie Diochot and collaborators from the venom of the black mamba (Dendroaspis polylepis polylepis). is a potent and selective blocker of acid-sensing ion channels (ASIC). ASIC channels have been demonstrated to be implied in pain pathways and appear to be promising therapeutic targets.   rapidly and reversibly inhibits recombinant homomeric ASIC1a (IC50=55 nM) and heteromeric ASIC1a+ASIC2a (IC50=246 nM) or ASIC1a+ASIC2b channels (IC50=61 nM) but also human channels hASIC1b (IC50=192 nM) and  hASIC1a+hASIC1b (IC50=72nM).

 belongs to the family of three-finger toxins and has no sequence/structural homology with either PcTx1 or APETx2 differs from mambalgin-2 by one amino acid. Both have demonstrated a similar activity. has no effect on ASIC2a, ASIC3, ASIC1a+ASIC3 and ASIC1b+ASIC3 channels, as well as on TRPV1, P2X2, 5-HT3A, Nav1.8, Cav3.2 and Kv1.2 channels.

Fig 1: Dose-response curve of the effect of synthetic #MAM001 on ASIC1a current recorded in Xenopus oocytes. In this system, an IC50 of 21 nM was determined.

 

技术资料

氨基酸序列:

LKC3YQHGKVVTC12HRDMKFC19YHNTGMPFRNLKLILQGC37SSSC41SETENNKC49C50STDRC55NK-OH

二硫键:Cys3-Cys19, Cys12-Cys37, Cys41-Cys49, Cys50-Cys55

长度 (aa) 57

分子式: C272H429N85O84S10 

分子量:6554.59 Da

外观:White lyophilized solid

可溶性:water or saline buffer

CAS 号:not available

来源:Synthetic

纯度:> 98%

 

产品信息

货号

名称

规格

MAM001-50010

50ug/100ug/5×10ug

 

北京群晓科苑是Smartox Biotechnology授权代理商,如果您对Smartox产品感兴趣,咨询。

留言框

  • 产品:

  • 您的单位:

  • 您的姓名:

  • 联系电话:

  • 常用邮箱:

  • 省份:

  • 详细地址:

  • 补充说明:

  • 验证码:

    请输入计算结果(填写阿拉伯数字),如:三加四=7
在线咨询
电话咨询
13581534696
关注微信