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ω-Conotoxin-SO3 (ω-漏斗网蛛毒素SO3 )

简要描述:Smartox Biotechnology是*一家专门生产动物毒液多肽毒素,用于细胞离子通道功能研究的生物医药公司。多肽毒素在生物制药领域具有重要的使用价值。

  • 产品型号:08CON013
  • 厂商性质:代理商
  • 更新时间:2024-03-26
  • 访  问  量:1626

产品介绍

ω-Conotoxin-SO3 (ω-漏斗网蛛毒素SO3 ) 

Selective blocker of N-type calcium channels

N型钙通道选择性阻断剂

 

ω-conotoxin SO-3 is a selective blocker of N-type voltage-sensitive calcium channels. EC50 for ω-conotoxin SO-3 is 0.16 µM (similar to ω-conotoxin MVIIA) on HVA calcium currents. ω-conotoxin SO-3 did not show any inhibiting effects on L-type, P/Q-type and R-type currents at 3 µM concentration. ω-conotoxin SO-3 has no effect on voltage-sensitive sodium currents, delayed rectifier potassium currents and transient outward potassium currents. At 3 µM, the inhibition amounts of HVA ICa was very similar between ω-conotoxin SO-3 and ω-conotoxin MVIIA (~ 32%). Their inhibitory effects are almost fully reversible but their half-time for recovery are different (~ 7.5 min for ω-conotoxin SO-3 and  ~ 4.14 min for ω-conotoxin MVIIA). ω-conotoxin SO-3 displays an analgesic potency similar to ω-conotoxin MVIIA in a range of acute and chronic pain models in rodents, but has less adverse effects compared with identical dosages of ω-conotoxin MVIIA injected intrathecally.

 

ω-Conotoxin-SO3 (ω-漏斗网蛛毒素SO3 )技术资料

 

氨基酸序列:

Cys1-Lys-Ala-Ala-Gly-Lys-Pro-Cys8-Ser-Arg-Ile-Ala-Tyr-Asn-Cys15-Cys16-Thr-Gly-Ser-Cys20-Arg-Ser-Gly-Lys-Cys25-NH2 

二硫键:Cys1-Cys16, Cys8-Cys20 and Cys15-Cys25 

长度 (aa)25

分子式: C100H165N35O32S6 

分子量: 2567.07 Da

外观:White lyophilized solid

可溶性: water and saline buffer

CAS 号:not available 

来源:Synthetic

纯度:> 97 %

 

产品信息

08CON013-00100

ω-conotoxin SO3(ω-漏斗网蛛毒素SO3 )

       0.1mg

 

08CON013-00500

ω-conotoxin SO3(ω-漏斗网蛛毒素SO3 )

0.5mg

 

08CON013-01000

ω-conotoxin SO3(ω-漏斗网蛛毒素SO3

1mg

 

 

 

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